At the Swiss Open Gstaad, Berrettini won his first ATP title, defeating Roberto Bautista Agut in the final.
He also won his first ATP doubles title at the same event, partnering with Daniele Bracciali.
At the Hungarian Open, Berrettini won his second ATP singles title, defeating Filip Krajinović in the final.
As the 17th seed at Wimbledon, Berrettini reached the fourth round of a Grand Slam for the first time after defeating Diego Schwartzman in five sets. He then lost to eight-time champion Roger Federer comprehensively in 74 minutes. After congratulating Federer for his win during their post-match handshake, Berrettini jokingly asked Federer, "Thanks for the tennis lesson, how much do I owe you?"
As world number 8, Berrettini claimed the final spot in the 2019 ATP Finals in London. There, he lost his opening two round robin matches to Novak Djokovic and Roger Federer, before becoming the first Italian man to win a match at the event by defeating Dominic Thiem.
Berrettini's strong performance advanced Italy to the final of the 2021 ATP Cup against Russia, where he lost to Daniil Medvedev in straight sets.
At the Australian Open, Berrettini reached the quarterfinals for the first time, defeating Carlos Alcaraz in five sets and Pablo Carreño Busta en route. He became the first man born in the 1990s and the first Italian man to reach the quarterfinals at all four majors. He became the first Italian man to reach the singles semifinals at the tournament after defeating Gaël Monfils in five sets In the semifinals, he lost to Rafael Nadal in four sets. As a result of his run, he improved to a career-high ranking of World No. 6.
His social media accounts have about 1.2 million followers, so he helps many brands by promoting their products and services.
Matteo Berrettini's net worth is currently estimated at $7 million.
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Matteo Berrettini’s father is Luca Berrettini.
Matteo Berrettini’s mother is Claudia Bigo.
Siblings: Matteo Berrettini has a brother named Jacopo Berrettini.